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1774, Vanuatu, Ciguatera

After eating fresh fish caught off the coast of Vanuatu (South Pacific), members of Captain Cook’s crew experienced illness characterized by upset stomach, vomiting, and weakness. These symptoms are indicative of ciguatera poisoning, which occurs when fish accumulate ciguatoxins, produced by members of the dinoflagellate genus Gambierdiscus. Read more here.